Generic & trade name:
N-acetyl-p-aminophenol, Ofirmev, Tylenol, Valorin, Acephen
Antipyretic, Nonopioid analgesic
Pregnancy Category B; C (IV)
PO: (Adults >12 yr):
325–650 mg q 4-6 hr
(not to exceed 3g or 2g/24 hr in patients with hepatic or renal impairment)
IV: (Adults ≥13 yr and ≥50 kg): 1000 mg q 6 hr or 650 mg q 4 hr (not to exceed 1000 mg/dose, 4 g/day, and less than 4 hr dosing interval).
IV: (Adults ≥13 yr and <50 kg): 15 mg/kg q 6 hr or 12.5 mg/kg q 4 hr (not to exceed 15 mg/kg/dose, 75 mg/kg/day, and less than 4 hr dosing interval).
Relief of mild to moderate pain
Reduction of fever
Inhibits synthesis of prostaglandins that serve as mediators of pain and fever, primarily in CNS
1st generation NSAIDs
(COX-1 and COX-2 inhibitors):
◯ Ibuprofen (Motrin, Advil)
◯ Naproxen (Naprosyn)
◯ Indomethacin (Indocin)
◯ Diclofenac (Voltaren)
◯ Ketorolac (Toradol)
◯ Meloxicam (Mobic)
2nd generation NSAIDs
(selective COX-2 Inhibitor):
◯ Celecoxib (Celebrex)
and VITAL SIGNS
SIDE EFFECTS and CONTRAINDICATIONS
(most common & life threatening/life threatening in ALL CAPS)
ACUTE RENAL FAILURE
Acute toxicity that results in liver damage with early symptoms of nausea, vomiting, diarrhea, sweating, and abdominal discomfort progressing to hepatic failure, coma, and death.
Acetaminophen slows the metabolism of warfarin (Coumadin), leading to increased levels of warfarin. This places clients at risk for bleeding (bruising, petechiae, hematuria).
Alcohol increases the risk of liver damage.
Half-life: Adults: 1–3 hr. *Depends on dose **Antipyretic effects
• Assess • Administration
• Teaching • Toxicity/overdose
• IV Compatibility
Advise clients to take medication with food or with a full glass of water or milk. Advise clients to avoid alcohol. Observe for signs of bleeding.
Advise clients to take acetaminophen as prescribed and not to exceed 4 g/day and about the potential risk of liver damage with consumption of alcohol.
Instruct clients to observe for signs of bleeding (bruising, petechiae, hematuria). Monitor PT and INR levels and adjust dosages of warfarin accordingly.
In the event of an overdose, administer acetylcysteine (Mucomyst), the antidote for acetaminophen, to prevent liver damage.